郝衛東

生殖發育毒理學、免疫毒理學🚆、環境毒理學👨🏼‍🦱、食品毒理學

1. 國家重點研發計劃課題，2017YFC1600203，基於毒作用機製和健康效應終點的食品稀土元素和添加劑的安全性評估，2018/01-2021/12🥞，主持

2. 國家新藥創製科技重大專項，2009ZX09301-010，綜合性創新藥物研究開發技術大平臺（意昂体育平台）—新藥安全性評價平臺，2009/01-2010/12，主持

3. 國家自然科學基金面上項目𓀉，82073586🍤，2-乙酰基-4-(1,2,3,4-四羥基丁基)咪唑引起淋巴細胞減少作用及其機製研究☠️，2021/01-2024/12🪲🙆🏽‍♀️，主持

4. 國家自然科學基金面上項目，81773466，矮壯素的生殖毒性及其影響睾酮合成的HPG軸調節機製研究，2018/01-2021/12，主持

5. 國家自然科學基金面上項目🧏🏿‍♂️，81473002, 矮壯素的發育毒性及其GH-IGF軸調節機製研究，2015/01-2018/12，主持

6. 國家自然科學基金面上項目，81273112🪅🦴，TAK1介導激活輔助T細胞在三氯乙烯引發藥疹樣皮炎和免疫性肝損傷中的作用， 2013/01-2016/12🐊，主持

7. 國家自然科學基金面上項目，30972501🙋🏽‍♂️，信號轉導通路和表觀遺傳模式在雙酚A神經發育毒性中的作用🦠，2010/01-2012/12，主持

8. 國家自然科學基金面上項目，30771821⛳️🕓，植物雌激素與環境雌激素發育毒性的聯合作用及其機製研究，2008/01-2010/12，主持

9. 國家自然科學基金青年項目，39600123🤞🏽，太陽光及紫外線照射誘發基因突變的分子機理，1997/01-1999/12👩🏻‍🎤，主持

10. 北京市自然科學基金面上項目，7182083，藍光剝奪對情緒的影響及視黑質介導的內在光傳導機製，2018/01-2020/12，主持

11. 北京市自然科學基金面上項目，7082054，雙氫青篙素抗光變態反應性接觸性皮炎的作用環節研究，2008/01-2010/12🫰🏽，主持

12. 北京市自然科學基金面上項目🈳，5062025🏚，絲裂原活化蛋白激酶信號通路在重金屬低劑量興奮中作用，2006/01-2008/12🧗🏼‍♀️，主持

13. 北京市科技創新基地培育與發展專項，Z151100001615035，食品中化學物發育毒性作用評價方法及機製研究，2015/07-2016/07🖖，主持

1. Qianqian Xiao1, Xiaohong Hou, Chenping Kang, Linglu Xu, Lilan Yuan, Zhe Zhao, Qinghe Meng, Jianjun Jiang, Weidong Hao*, Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary rat Leydig cells👼🏽，Toxicology Letters, 2021, 356 :161–171

2. Qianqian Xiao, Xiaohong Hou, Chenping Kang, Bayindala Xiagedeer , Hong Hu , Qinghe Meng , Jianjun Jiang, Weidong Hao*, Effects of prenatal chlorocholine chloride exposure on pubertal development and reproduction of male offspring in rats, Toxicology Letters, 2021, 351 :28–36

3. Bayindala Xiagedeer, Xiaohong Hou, Qi Zhang, Hong Hu, Chenping Kang, Qianqian Xiao, WeidongHao*， Maternal chlormequat chloride exposure disrupts embryonic growth and produces postnatal adverse effects, Toxicology, 2020, 442:152534

4. Xiaohong Hou, Hong Hu, Bayindala Xiagedeer, Pengmin Wang, Chenping Kang, Qi Zhang, Qinghe Meng, Weidong Hao*. Effects of chlorocholine chloride on pubertal development and reproductive functions in male rats, Toxicology Letters,  2020, 319:1-10.

5. Bayindala Xiagedeer, Chenping Kang, Xiaohong Hou, Hong Hu, Qianqian Xiao, Weidong Hao*，Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis, Toxicology，429:1-9

6. Yao Pan, Xiaohong Hou, Qinghe Meng , Xiaohua Yang , Lanqin Shang,  XuetaoWei , Weidong Hao*，The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro，Toxicology and Applied Pharmacology，2019🏄🏼，381:1-14

7. Xiaohong Hou, Dan Huang, Qinghe Meng, Qi Zhang, Lixia Jia, Siqi Wang, Zhiyuan Cheng, Shuang Wu, Lanqin Shang, Jianjun Jiang, Weidong Hao*, Pubertal chlorocholine chloride exposure inhibits testicular testosterone synthesis by down-regulating  steroidogenic enzymes🧑🏿‍🌾🪲，Toxicology Letters, 2018, 288:17-24

8. Dan Huang🤲🏻，Shuang Wu，Xiaohong Hou，Lixia Jia👝，Qinghe Meng🧝‍♂️👩🏽‍🍼，Hongqian Chu，Jianjun Jiang🏸，Lanqin Shang，Weidong Hao*🧜🏼‍♀️，The Skeletal developmental toxicity of chlormequat chloride and its underlying mechanisms，Toxicology，2017, 381:1-9

9. Hongqian Chu💂🏼‍♂️，Jing Shang🤷🏽‍♂️，Ming Jin🏂🏼👨🏼‍🍼，Yueyue Chen，Yao Pan，Yuan Li𓀇，Xi Tao，Zhiyuan Cheng✍🏻，Qinghe Me🃏，Qian Li，Guang Jia🎓，Tong Zhu，Weidong Hao*🐉，Xuetao Wei*，Comparison of lung damage in mice exposed to black carbon particles and 1,4-naphthoquinone coated black carbon particles，Science of the Total Environment, 2017, 580:572-581

10. Hongqian Chu🤚，Jing Shang，Ming Jin❔，Qian Li👼🏽，Yueyue Chen，Hongpeng Huang，Yuan Li，Yao Pan，Xi Tao，Zhiyuan Cheng🧜🏽‍♂️，Qinghe Meng💪🏽，Guang Jia，Tong Zhu🛹，Xuetao Wei*，Weidong Hao*，Comparison of lung damage in mice exposed to black carbon particles and ozone-oxidized black carbon particles🏋🏽‍♂️，Science of the Total Environment, 2016, 573:303-312