葛顥

隨機過程和統計學與物理、化學🔘、生物的交叉

1、 與非平衡態統計物理有關的概率論和隨機過程數學理論研究；

2、高維統計學習在生物上的應用🐠，主要解決實際的生物學數據分析問題🫸🏽；

3、隨機動力學模型在生物學上的應用👳🏿，主要針對單細胞層面的動力學問題。

1. 國家自然科學基金青年項目(10901040🪺，2010-2012):　隨機過程在現代非平衡統計物理及生物化學模型中的應用　主持 16萬；

2. 全國優秀博士學位論文專項資助(2011-2015)：生物化學和統計物理中的隨機過程模型研究主持 56萬；

3. 國家自然科學基金面上項目(21373021，2014-2017):　由DNA介導的別構效應祥光理論與模型研究 主持 60萬；

4. 科技部863計劃(2015AA020406, 2015-2017)：單細胞實時動態三維成像新技術及裝置研究 參與  60萬；

5. 國家自然科學基金委優秀青年項目(11622101，2017-2019)：隨機過程與生物物理化學的交叉學科研究 主持 130萬;

1.You, Z.Y., Li, L.Y., Lu, J.F. * and Ge, H. *: Integrated tempering enhanced sampling method as the infinite switching limit of simulated tempering. J. Chem. Phys. 149, 084114 (2018) (*co-corresponding authors)

2.Gao, S., …, Ge, H. *, Qiao, J. * and Tang, F.C. *: Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing. Nat. Cell Biol. 20, 721–734 (2018) (*co-corresponding authors)

3.Ge, H., Wu, P.P., Qian, H. and Xie, X.S.: Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stablizing the uninduced phenotypic state. Plos Comput. Biol. 14(3): e1006051 (2018)

4.Ge, H., Jiang, D.Q. and Jia, C.: Cycle symmetry, limit theorems, and fluctuation theorems for diffusion processes on the circle. Stoc. Proc. Appl. 127: 1897–1925 (2017)

5.Zhao, Z.Q., Xie, X.S. * and Ge, H. *: Nonequilibrium Relaxation of Conformational Dynamics Facilitates Catalytic Reaction in an Elastic Network Model of T7 DNA Polymerase. J. Phys. Chem. B 120, 2869−2877 (2016) (*co-corresponding authors)

6.Ge, H., Qian, H. and Xie, X.S.: Stochastic phenotype transition of a single cell in an intermediate region of gene state switching. Phys. Rev. Lett. 114, 078101 (2015)

7.Chong, S.S., Chen, C.Y., Ge, H. and Xie, X.S.: Mechanism of transcriptional bursting in bacteria. Cell 158, 314–326 (2014)

8.Ge, H., Qian, M. and Qian, H.: Stochastic theory of nonequilibrium steady states. Part II: Applications in chemical biophysics. Phys. Rep. 510, 87-118 (2012)

9.Ge, H. and Qian, H.: The physical origins of entropy production, free energy dissipation and their mathematical representations. Phys. Rev. E 81 051133 (2010)

10.Ge, H. and Qian, H.: Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system. Phys. Rev. Lett. 103, 148103 (2009)